Ubiquitin-like protein activation
نویسندگان
چکیده
منابع مشابه
The Ubiquitin-Like Protein FAT10 Mediates NF- B Activation
NFB is a central mediator of innate immunity and contributes to the pathogenesis of several renal diseases. FAT10 is a TNF–inducible ubiquitin-like protein with a putative role in immune response, but whether FAT10 participates in TNF–induced NFB activation is unknown. Here, using renal tubular epithelial cells (RTECs) derived from FAT10 / and FAT10 / mice, we observed that FAT10 deficiency abr...
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Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.
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SUMO (Small Ubiquitin-related Modifier) is a small protein that covalently attaches to a lysine residue of another protein in a reversible fashion. SUMO attachment to its substrate proteins causes changes in the localization, activity, or binding partners of the substrate. SUMO has been shown to play a role in a multitude of processes; these include chromosome segregation, cell cycle progressio...
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1. INTRODUCTION Proteomes are significantly more complex than genomes and transcriptomes due to protein processing and extensive post-translational modification (PTM) of proteins. Hundreds of different modifications exist. Release 66 of the RESID database 1ferent modifications, including small chemical modifications such as phosphorylation, acetylation, and methylation and modification by small...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2004
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1207393